Natsume's Book of Friends is written and illustrated by Yuki Midorikawa and published in Japan by Hakusensha. It began serialization in 2005 in the bimonthly shōjo (aimed at teenage girls) manga magazine named LaLa DX; in 2008, its serialization switched over to the monthly sister magazine LaLa. The chapters, all untitled, have been collected in twelve tankōbon volumes as of July 2011.
The series is licensed in English in North America by Viz Media, with the first volume published in January 2010. It is also licensed in French by Delcourt, in South Korea by Haksan, in Taiwan by Tong Li, and in Thailand by Bongkoch Publishing.
Natsume's Book of Friends has been adapted as a series of drama CDs, as well as an anime television series produced by Brain's Base, which was broadcast on TV Tokyo in two seasons in 2008 and 2009.